Monira - The cause of blood clots can often be determined, but not always. Blood clots most often manifest as deep vein thrombosis in the lower extremity.
The cause of blood clots is often physiologic and related to medications, or trauma. Blood clots can occur in people with no specific risk factors. In these people the cause of blood clots can be related to genetic factors.
The most common genetic cause of blood cloths is factor V Leiden. Other genetic causes of blood clots include the prothrombin gene mutation, protein C deficiency, protein S deficiency, anti-thrombin III deficiency, and the MTHFR Gene mutation.
Acquired factors that can be the cause of blood clots include the lupus anticoagulant and anticardiolipin antibody.
zeldaslexicon - There are multiple factors that can contribute to the formation of a blood clot, too many to describe in detail here! But in general, factors leading to thrombosis (the medical term for a blood clot) can be grouped into three categories. These three factors are known as Virchow's Triad and include:
Hypercoagulability - this includes people who suffer from coagulopathies (disorders of the blood wherein the blood is more likely to form clots). Certain hormonal states (like pregnancy) may also be included here.
Stasis - being immobile for long periods of time can increase risk for thrombosis. This is why it's advisable to get up and walk around on very long plane rides - people have been known to develop a deep vein thrombosis (DVT) after a very long plane or car ride.
Trauma/injury - getting injured, having surgery, breaking a bone - all these can increase risk for clot formation.
The more factors of Virchow's triad that are seen in a patient's profile, the higher the risk for thrombosis formation. For example, a friend of mine has Protein C deficiency (a clotting disorder). While pregnant, she was injured in a fall and subsequently spent a few days in bed. She had all three factors of Virchow's Triad in play - and yes, she developed a blood clot!
im just wondering
Monira - The cause of blood clots can often be determined, but not always. Blood clots most often manifest as deep vein thrombosis in the lower extremity.
ReplyDeleteThe cause of blood clots is often physiologic and related to medications, or trauma. Blood clots can occur in people with no specific risk factors. In these people the cause of blood clots can be related to genetic factors.
The most common genetic cause of blood cloths is factor V Leiden. Other genetic causes of blood clots include the prothrombin gene mutation, protein C deficiency, protein S deficiency, anti-thrombin III deficiency, and the MTHFR Gene mutation.
Acquired factors that can be the cause of blood clots include the lupus anticoagulant and anticardiolipin antibody.
zeldaslexicon - There are multiple factors that can contribute to the formation of a blood clot, too many to describe in detail here! But in general, factors leading to thrombosis (the medical term for a blood clot) can be grouped into three categories. These three factors are known as Virchow's Triad and include:
ReplyDeleteHypercoagulability - this includes people who suffer from coagulopathies (disorders of the blood wherein the blood is more likely to form clots). Certain hormonal states (like pregnancy) may also be included here.
Stasis - being immobile for long periods of time can increase risk for thrombosis. This is why it's advisable to get up and walk around on very long plane rides - people have been known to develop a deep vein thrombosis (DVT) after a very long plane or car ride.
Trauma/injury - getting injured, having surgery, breaking a bone - all these can increase risk for clot formation.
The more factors of Virchow's triad that are seen in a patient's profile, the higher the risk for thrombosis formation. For example, a friend of mine has Protein C deficiency (a clotting disorder). While pregnant, she was injured in a fall and subsequently spent a few days in bed. She had all three factors of Virchow's Triad in play - and yes, she developed a blood clot!